Cell Surface Delivery of TRAIL Strongly Augments the Tumoricidal Activity of T Cells
نویسندگان
چکیده
منابع مشابه
Cell surface delivery of TRAIL strongly augments the tumoricidal activity of T cells.
PURPOSE Adoptive T-cell therapy generally fails to induce meaningful anticancer responses in patients with solid tumors. Here, we present a novel strategy designed to selectively enhance the tumoricidal activity of T cells by targeted delivery of TNF-related apoptosis-inducing ligand (TRAIL) to the T-cell surface. EXPERIMENTAL DESIGN We constructed two recombinant fusion proteins, anti-CD3:TR...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2011
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-11-0303